What Is Hepatitis C? Symptoms, Causes, Diagnosis, Treatment, and Prevention

Hepatitis is an inflammation of the liver, and hepatitis C is liver inflammation caused by the hepatitis C virus (HCV).

Before scientists identified HCV in 1989, hepatitis C was called non-A, non-B hepatitis.

For many years, scientists recognized six major strains of HCV, or HCV genotypes, and dozens of additional subtypes. Scientists then identified genotype 7 from Central Africa in 2014

and genotype 8 from India in 2018,

according to a pair of studies.

Though these genotypes appear to affect people similarly, they respond differently to treatments, and it’s possible to be infected with more than one HCV genotype at the same time.

Whatever the genotype, hepatitis C is considered either acute (clears up within six months) or chronic (lasts more than six months).

Common Questions & Answers

How is hepatitis C transmitted?
Hepatitis C is transmitted when infected blood enters the body of someone who isn’t infected. One common way that transmission occurs is through the sharing of needles and syringes.
What are common symptoms of hepatitis C?
Signs and symptoms may include jaundice, fatigue, fever, dark urine, gastrointestinal issues, loss of appetite, and joint pain.
How is hepatitis C diagnosed?
Diagnosis is based on medical history, a physical exam to look for signs of liver damage, and the results from certain blood tests.
What factors raise your risk for hepatitis C?
Factors that increase your risk include working in a healthcare setting, having HIV, receiving a tattoo or piercing with nonsterile instruments, and undergoing kidney dialysis.
What is cirrhosis?
Cirrhosis is permanent scarring of the liver that prevents the organ from functioning as it should. People with cirrhosis have an increased risk of liver cancer.

Signs and Symptoms of Hepatitis C

About 70 to 80 percent of people who become infected with acute hepatitis C do not show any symptoms at first.

But those who do may have mild to severe symptoms, such as:
  • Jaundice
  • Fatigue
  • Fever
  • Dark urine
  • Gastrointestinal issues
  • Loss of appetite
  • Joint pain
  • Weight loss

People with chronic hepatitis C, on the other hand, often don’t show any symptoms until the liver becomes damaged, which could be years after exposure.

Learn More About Signs and Symptoms of Hepatitis C

Causes and Risk Factors of Hepatitis C

Hepatitis C is transmitted when the blood of an infected person enters the body of someone who isn’t infected.

Prior infection doesn’t offer protection against the virus, and being cured of hepatitis C does not result in immunity against reinfection, says Carlos Malvestutto, MD, MPH, an infectious disease physician at The Ohio State University Wexner Medical Center in Columbus. It’s possible to become infected with the same or a different strain of HCV after you’ve cleared an initial infection.

Before 1992, when widespread screening of the blood supply began, people could contract the virus through blood transfusions and organ transplants.

Similarly, the virus could be transmitted to people who received clotting factor concentrates — used in the treatment of hemophilia — before 1987, when less advanced fabrication methods were used for those products.

This is likely a factor in the higher incidence of hepatitis C among baby boomers, who received blood transfusions before better screening was implemented.
Since the use of advanced screening techniques, the risk of contracting the virus from a transfusion is considered to be less than one per two million units transfused.

Today, the most common ways that transmission occurs are:

Using personal care items — including razors and toothbrushes — that have come in contact with blood infected with HCV can put you at risk of hepatitis C.

“Hepatitis C can be easily transmitted with any blood-to-blood contact (much more easily than HIV),” Dr. Malvestutto says. “There have been cases of transmission through sharing of razors or sharing ‘straws’ to inhale drugs nasally.”

Though less common, it’s also possible to acquire a hepatitis C infection by having unprotected sex with someone who has the virus.

Given that hepatitis C is spread through blood contact, an infected mother cannot give her baby hepatitis C through breastfeeding, and you cannot contract the virus through saliva (kissing).

Some factors that increase your risk of hepatitis C:

  • Working in the healthcare setting or another field in which you have regular contact with blood
  • Having HIV (about 21 percent of people with HIV also have hepatitis C)

  • Receiving a tattoo or piercing with nonsterile instruments
  • Undergoing dialysis for many years

Hepatitis C has some surprising ways of showing up. For example, your birth date alone may put you at a higher risk. Healthcare professionals and members of the military are also at greater risk.

10 Surprising Reasons You’re at Risk of Hepatitis C

How Is Hepatitis C Diagnosed?

Screening for hepatitis C is important because the symptoms don’t often show up until complications have already developed. Your doctor will likely recommend screening for hepatitis C if you have a high chance of being infected or if you were born between 1945 and 1965.

In addition to taking your medical history and performing a physical exam to look for signs of liver damage, your doctor will use the results of certain blood tests to make a diagnosis.

healthy liver vs hepatitis c liver
An image showing a healthy liver and a liver affected by chronic hepatitis C with cirrhosis.iStock

An initial blood test screens for HCV antibodies — proteins your body produces in reaction to the presence of the hepatitis virus. If the result is negative, it means you’ve never had HCV in your blood. If the result is positive, you were exposed to HCV at some point.

If the antibody test is positive, your doctor will conduct another blood test that looks for the RNA (genetic material) of HCV in your blood. There are qualitative HCV RNA tests and quantitative ones. A qualitative test determines the presence or absence of the virus in your body, while the quantitative RNA test measures the viral load, or how much virus is in the blood.

Your doctor may also order the quantitative hepatitis C RNA test while you are undergoing treatment to find out if the amount of virus in your blood is changing.

Another blood test will also be used to determine which genotype (or genotypes) of HCV you have, as that will affect your treatment plan.

Your doctor may conduct other blood tests to assess liver damage.

Imaging tests — computerized tomography (CT) scansmagnetic resonance imaging (MRI), or ultrasound — may be performed to see if your hepatitis C has caused liver cancer or cirrhosis (irreversible scarring of the liver). If more information is needed, you may undergo a liver biopsy, in which a liver tissue sample is removed with a thin needle inserted through your skin and into your liver.

Prognosis of Hepatitis C

Because hepatitis C is treatable, the prognosis is generally good. In fact, medicine can completely cure most cases of hepatitis C. Sometimes the body even clears hepatitis C on its own.

Duration of Hepatitis C

Hepatitis C comes in two forms: acute and chronic. About 15 to 25 percent of people who become infected with hepatitis C only develop an acute infection, which spontaneously clears from the body within six months.

The other 75 to 85 percent of people go on to become hepatitis C carriers and develop a chronic infection, which can last a lifetime if left untreated. Chronic hepatitis C can lead to hepatitis C-related complications, including chronic liver disease, cirrhosis, and liver cancer.

Treatment and Medication Options for Hepatitis C

The last few years have seen extraordinary advances in the treatment of hepatitis C.

For decades, the standard treatment was a combination antiviral therapy consisting of a pegylated interferon (a synthetic version of a protein secreted by immune system cells in response to pathogens) and ribavirin (Virazole), sometimes called PEG-riba therapy. This involved weekly injections of the pegylated interferons along with twice-daily oral doses of ribavirin. Sometimes, interferon was prescribed without ribavirin.

Until fairly recently, the treatment by interferon lasted six months to a year and cured only 40 to 50 percent of hepatitis C patients. The painful injections often made patients feel ill with flu-like symptoms.

Traditional treatment injections could also worsen very advanced liver disease.

But now, hepatitis C can be treated with a number of direct-acting antiviral pills that act faster and much more effectively than the older interferon treatment. These combination oral medicines have 90 to 100 percent cure rates, and they work in weeks instead of months. Some of these drugs may be used in combination with ribavirin.

Medication Options

The choice of medication and length of treatment depends on which genotype of the virus a patient has, how much liver damage they’ve sustained, and whether they’ve already been treated for hepatitis C. Medication options include:

People with hepatitis C should avoid alcohol, as it can damage the liver. Check with your doctor before taking any medication or supplements that might also damage the liver. If liver damage is present, the CDC recommends asking your doctor about getting vaccinated against hepatitis A and hepatitis B. A vaccine for hepatitis C is not yet available.

If HCV-related cirrhosis has led to liver failure, a liver transplant is the only real treatment.

Learn More About How Hepatitis C Is Treated

Complementary and Integrative Approaches

Though hepatitis C is easily treatable through conventional medicine, some people prefer to explore complementary and integrative approaches to treatment for hepatitis C. These include:

  • Milk thistle
  • Vitamin D
  • SNMC (Stronger Neominophagen C)
  • CH100 (Cathy Herbal Tablet)
  • Thymus and other extracts
Other therapies, such as yoga, essential oils, acupuncture, and massage therapy, cannot rid the body of HCV, though they may help improve mood and reduce stress and pain associated with hepatitis C.

Learn More About Alternative and Complementary Therapies for Hepatitis C

Prevention of Hepatitis C

There is no vaccine for hepatitis C.

The best way to avoid getting hepatitis C is to reduce your risk factors, such as by:

  • Not using intravenous drugs
  • Using only sterile injection equipment if you do inject drugs, and not reusing or sharing your equipment
  • Not sharing personal care items that might have blood on them, including razors, toothbrushes, and nail clippers
  • Safely handling needles and other sharp equipment if you are a healthcare worker
  • Not getting a tattoo, body piercing, or acupuncture treatment from an unlicensed practitioner
  • Practicing safe sex

Complications of Hepatitis C

Approximately 10 to 20 percent of people with HCV develop cirrhosis — irreversible scarring of the liver that prevents the organ from functioning as it should — over a period of two to three decades.

People with cirrhosis have an increased risk for liver cancer.

The most common complication of cirrhosis is portal hypertension — increase in pressure in the vein that carries blood between the digestive organs and liver.

This, in turn, can lead to:
  • Buildup of fluid in the abdomen, feet, ankles, or legs
  • Enlarged spleen
  • Enlarged blood vessels in the esophagus and stomach, which are more susceptible to tear and cause internal bleeding

Cirrhosis can eventually lead to end-stage liver disease, or liver failure, which is accompanied by several debilitating symptoms, including a buildup of toxins in the brain that can result in cognitive decline and coma. Cirrhosis also increases the risk for liver cancer.

“Unfortunately, HCV can destroy the liver and cause a horrendous death,” says Andrea Branch, PhD, a professor of medicine and liver diseases at the Icahn School of Medicine at Mount Sinai in New York City. “To get the maximum benefit of treatment, it is important to treat HCV as soon as the infection is diagnosed.”

If you have hepatitis C, you may also be at a higher risk of getting or developing complications from COVID-19. The CDC notes that adults living with hepatitis C or B may be at a higher risk of severe illness with COVID-19 and suggests this may be more likely if the conditions are not properly managed.

A 2020 research paper found that patients living with chronic liver disease (including hepatitis C) were at an increased risk of getting COVID-19 and had higher mortality and hospitalization rates compared with COVID-19 patients without chronic liver disease.

These disparities were more pronounced among African Americans living with chronic liver disease.
People with hepatitis C should maintain a healthy lifestyle and continue with any treatments they are undergoing to manage their condition.

Learn More About the Complications of Hepatitis C: How It Affects Your Body in the Short and Long Term

Research and Statistics: Who Has Hepatitis C? How Many People Have Hepatitis C?

Health officials reported 4,136 cases of acute hepatitis C in 2019, but the CDC estimates that the actual number of acute cases is considerably greater than the number of reported cases in any year. The CDC put the real number of acute hepatitis C cases in 2019 at an estimated 57,500.

Chronic hepatitis C affects about 2.4 million Americans. On a global scale, an estimated 71 million people have chronic hepatitis C.

Of the total number of Americans with chronic hepatitis C, baby boomers — people born between 1945 and 1965 — account for 75 percent.

The CDC recommends everyone born during those years get tested for hepatitis C.
While baby boomers are more likely to be infected with hepatitis C than people in other age groups, a 2017 report found that new hepatitis C infections had nearly tripled over the previous five years, with the highest overall number of new infections affecting those ages 20 to 29. This is largely tied to the opioid epidemic in the United States and the increased use of injection drugs.

Despite these estimates, “we really do not know how many people are infected with HCV,” Dr. Branch says, adding that the U.S. estimates come from specific datasets that “do not include prisoners or the homeless and have too small a sample size to yield precise data.”

In an earlier study, men have been found to be less likely than women to spontaneously clear an acute infection from their blood.

Men have also been found to be more likely to develop liver complications from the infection.

Women with chronic infections are less likely to have disease progression, but the risk for fibrosis (initial scarring of the liver) in women changes over time and, as women age, they’re at increased risk of complications from hepatitis C infections.

It’s unclear how many people fail to get treatment in time and die from HCV-related issues. There were 15,713 reported deaths related to HCV in 2018, but this is likely a conservative estimate.

“HCV may be causing 3 to 5 times more deaths than we know,” Branch says. “Better information about the number of HCV-related deaths would help make HCV testing and treatment more of a priority.”

Related Conditions and Causes of Hepatitis C

Other types of viral hepatitis include hepatitis A, B, D, and E.

Hepatitis A and E are generally acquired from contaminated food and drink, while hepatitis B and D are transmitted via bodily fluids. You can only get hepatitis D if you already have hepatitis B.

Though viruses are the most common causes of hepatitis, there are also forms of nonviral hepatitis, including:

  • Alcoholic hepatitis caused by prolonged alcohol abuse

  • Autoimmune hepatitis, in which the immune system attacks healthy liver cells

  • Drug-induced hepatitis from various meds, including acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), anabolic steroids, birth control pills, and tetracycline (Sumycin)

Learn More About Health Conditions Linked to Hepatitis C

Resources We Love

Favorite Orgs for Essential Hep C Info

Hepatitis C Association

This organization is dedicated to educating the public about all aspects of the hepatitis C virus. The site presents the latest hep C news and events, as well as resources for those without insurance. The association is the managing partner for the Help4Hep toll-free support and resource line at 877-435-7443.

American Liver Foundation

The viral infection hep C can take its toll on the liver. This foundation supports education, advocacy, and research for the prevention of liver disease. It has a nationwide network of offices ready to help individuals with any related questions.

United Network for Organ Sharing

One of the most common reasons for liver transplantation in the United States is organ failure due to hep C. This network serves as a comprehensive resource for those exploring liver transplant options, organ donation, and medical advances. Profiles of people who have had transplants and connections to support groups are available.

Favorite Hep C Financial Resources

NeedyMeds

This nonprofit devotes its energies to help people afford healthcare and medication. It offers a free drug discount card that extends a discount of up to 80 percent at more than 65,000 pharmacies nationwide. Anyone (and their family and friends) can use the card regardless of income level or insurance status.

RxAssist

RxAssist guides people to free or low-cost medicine programs. Visitors to the website can type a drug’s name into the search tool to find patient assistance programs that can help with costs. The group also gives a wealth of information on various drug discount cards.

Patient Advocate Foundation Co-Pay Relief

Those who qualify can get awards of up to $15,000 a year to pay for hep C treatment. Eligibility requirements include an income below 400 percent of the federal poverty guidelines. In addition, the foundation presents links to other financial resources and pharmaceutical assistance programs.

Favorite Hep C Alternative Medicine Resource

National Center for Complementary and Integrative Health (NCCIH)

Although hep C can be successfully treated with modern medicine, many people turn to dietary supplements with the goal of curing their illness. The most commonly used is silymarin (milk thistle). Although the NCCIH says that no supplement is effective for hep C, the center provides the latest scientific data on a range of products, including probiotics, zinc, licorice root, and colloidal silver.

Favorite Hep C Support Networks

Hepatitis Central

This site gives a very detailed listing of live hep C support groups in cities across the country. Meetings are often for those undergoing treatment or people who have questions about treatment. A database that searches by ZIP code makes it simple to find a support group near you.

+supportgroups

This online support network has about 34,000 members at latest count. People can anonymously post about all concerns related to the disease, including issues about stigma, depression, and care.

Favorite Hep C Online Magazine and Blogs

Hep Mag

Hep Mag publishes articles about people living with hep C, and it offers a forum for people to ask questions and share stories and information with other readers. The online magazine also features a blog on funding, cures, liver disease, and related matters.

FeedSpot

FeedSpot, a feed compiling news from online sources, lists 20 top blogs and websites to explore concerning hepatitis C. Readers can connect with one another and find out about the latest drug research developments.

Favorite Sites for Hep C Products

Hep C can now be cured with an 8- to 12-week course of medication. The pharmaceutical companies that produce these drugs all present useful information and, in some cases, details on how to get the medication at a lower cost. Here are the latest hep C drugs approved by the FDA:

Additional reporting by Laura McArdle.

Editorial Sources and Fact-Checking

Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.

Sources

  1. Hepatitis C. San Francisco Department of Public Health.
  2. Hepatitis C Virus Genotype 7, a New Genotype Originating From Central Africa. Journal of Clinical Microbiology.
  3. Identification of a Novel Hepatitis C Virus Genotype From Punjab, India: Expanding Classification of Hepatitis C Virus Into 8 Genotypes. The Journal of Infectious Diseases.
  4. Hepatitis C Questions and Answers for the Public. Centers for Disease Control and Prevention.
  5. Hepatitis C Questions and Answers for Health Professionals. Centers for Disease Control and Prevention.
  6. People Coinfected With HIV and Viral Hepatitis. Centers for Disease Control and Prevention.
  7. Hepatitis C. National Institute of Diabetes and Digestive and Kidney Diseases.
  8. Hepatitis C Treatments Give Patients More Options. U.S. Food and Drug Administration.
  9. Hepatitis C and Dietary Supplements. National Center for Complementary and Integrative Health.
  10. Complementary and Integrated Medicine for Hepatitis C. U.S. Department of Veterans Affairs.
  11. Definition and Facts for Cirrhosis. National Institute of Diabetes and Digestive and Kidney Diseases.
  12. COVID-19 Severity and Mortality Among Chronic Liver Disease Patients: A Systematic Review and Meta-Analysis. Preventing Chronic Disease.
  13. COVID-19 Risk, Disparities, and Outcomes in Patients With Chronic Liver Disease in the United States. eClinicalMedicine (The Lancet).
  14. Hepatitis C. World Health Organization.
  15. CDC Now Recommends All Baby Boomers Receive One-Time Hepatitis C Test. Centers for Disease Control and Prevention.
  16. New Hepatitis C Infections Nearly Tripled Over Five Years. Centers for Disease Control and Prevention.
  17. Higher Clearance of Hepatitis C Virus Infection in Females Compared With Males. Gut.
  18. Acute Hepatitis C in a Contemporary US Cohort: Modes of Acquisition and Factors Influencing Viral Clearance. The Journal of Infectious Diseases.
  19. Natural History and Management of Hepatitis C: Does Sex Play a Role? The Journal of Infectious Diseases.
  20. Alcoholic Hepatitis: Symptoms and Causes. Mayo Clinic.
  21. Autoimmune Hepatitis. National Institute of Diabetes and Digestive and Kidney Diseases.
  22. Drug-Induced Liver Injury. MedlinePlus.

Resources

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